Min Qian Fudan.jpg

MS. MIN QIAN

Biodegradable Nanosystem for Debris-Mediated Photothermal Synergistic Immunotherapy

Incorporating carbon nanodots (CD) into mesoporous silica framework for extensive biomedicine, especially for the desirable cancer immunotherapy, is considered to be an unexplored challenge. Herein, a hydrogen bond/electrostatic-assisted co-assembly strategy was smartly exploited to uniformly incorporate polymer-coated CD into ordered mesoporous silica framework (CD@MSN). The obtained CD@MSN were not only biodegradable via the framework-incorporated CD-induced swelling, but also capable of gathering dispersive CD with enhanced photothermal effect and elevated targeting accumulation, which therefore can achieve photothermal imaging-guided photothermal therapy (PTT) in vitro and in vivo. Much interestingly, benefiting from the biodegraded debris, it was found that CD@MSN-mediated PTT can synergistically achieve immune-mediated inhibition of tumor metastasis via stimulating the proliferation and activation of NK cells and macrophages, and simultaneously up-regulating the secretion of corresponding cytokines (IFN-γ and Granzyme B). This work proposed an unusual synthesis of biodegradable mesoporous silica and provided an innovative insight into the biodegradable nanoparticles-associated anticancer immunity.

Formulation and Delivery